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Evaluation of potential mechanisms underlying genotype–phenotype correlations in multiple endocrine neoplasia type 2

✍ Scribed by Miše, N; Drosten, M; Racek, T; Tannapfel, A; Pützer, B M


Book ID
110070688
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
307 KB
Volume
25
Category
Article
ISSN
0950-9232

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Multiple Endocrine Neoplasia type 1 (MEN1) is an autosomal dominant disease characterized by endocrine tumors of the parathyroids, the pancreatic islets, and the anterior pituitary. The MEN1 gene encodes menin, a nuclear protein interacting with JunD/AP1, Smad3, NFkappaB, and other proteins involved