Evaluation of polymeric materials II. Screening of selected vinyls and acrylates as prolonged-action coatings

✍ Scribed by Robert Jay Nessel; H. George Dekay; Gilbert S. Banker

• Publisher: John Wiley and Sons
• Year: 1964
• Tongue: English
• Weight: 483 KB
• Volume: 53
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600530720

✦ Synopsis

Acrylic and vinyl polymers, copolymers, and derivatives were evaluated as potential sustained-action coatings. Based o n a screening of films of the polymeric materials for solubility characteristics, free him formation, and drug permeability, the n-butyl half ester of poly(methy1 vinyl ether)/maleic anhydride offered the most in vitro promise of controlling dru release. T h e n-butyl half ester had no cumulative toxic effects fased on a short-term feeding study.

N THE SELECTION of polymeric films for application as protective, enteric, or sustained-. .-.