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Evaluation of PIK3CA Mutation As a Predictor of Benefit From Nonsteroidal Anti-Inflammatory Drug Therapy in Colorectal Cancer

✍ Scribed by Domingo, E.; Church, D. N.; Sieber, O.; Ramamoorthy, R.; Yanagisawa, Y.; Johnstone, E.; Davidson, B.; Kerr, D. J.; Tomlinson, I. P. M.; Midgley, R.


Book ID
121387179
Publisher
American Society of Clinical Oncology
Year
2013
Tongue
English
Weight
229 KB
Volume
31
Category
Article
ISSN
0732-183X

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## Abstract Common single nucleotide polymorphisms (SNPs) in __SMAD7__ (18q21) have been linked to colorectal cancer (CRC) risk in genome‐wide association studies, but little is known about their effects on survival. SMAD7 regulates gastrointestinal inflammation by inhibiting transforming growth fa