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Evaluation of phenomena occurring during the preparation of matrix granules by the hot melt technique

✍ Scribed by János Bajdik; Anita Korbely; Klára Pintye-Hódi


Publisher
Springer Netherlands
Year
2010
Tongue
English
Weight
298 KB
Volume
104
Category
Article
ISSN
0022-5215

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Nimodipine (NM) solid dispersions (SD) were prepared by hot-melt extrusion with polyvinylpyrrolidone/vinyl acetate copolymer (PVP-VA; Kollidon VA64) as the carrier, then the extrudate was stored at different temperatures (20°C, 40°C, 60°C) after milling. Conventional differential scanning calorimetr