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Evaluation of Pharmacokinetic Interaction Between Cyclosporin A and Probucol in Rats

โœ Scribed by Mari Jiko; Ikuko Yano; Hiroko Wakasugi; Hideyuki Saito; Ken-ichi Inui

Book ID
110395060
Publisher
Springer US
Year
2002
Tongue
English
Weight
110 KB
Volume
19
Category
Article
ISSN
0724-8741

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Pharmacokinetic evaluation of the blood-
Pharmacokinetic evaluation of the blood-to-lymph transfer of cyclosporin a in rats
โœ Clarence T. Ueda; Michel Lemaire; Pierrette Misslin ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 518 KB

The blood-to-lymph transfer kinetics of cyclosporin A (CyA) were investigated in thoracic duct cannulated rats after a 3 mg kg-' i.v. bolus injection of tritium-labelled drug. Blood CyA concentrations declined bi-exponentially with a terminal half-life of 13.1 1.8 h. The appearance rate of CyA in th