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Evaluation of peri- and post-natal toxicity of policosanol in rats

✍ Scribed by Maria D. Rodríguez; Haydee Garcia

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
26 KB
Volume
18
Category
Article
ISSN
0270-3211

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✦ Synopsis

The effects of Policosanol, a newly developmented hypocholesterolemic drug administered during the perinatal and postnatal periods, were studied in Sprague-Dawley rats. This compound was administered orally to female rats at dose levels of 0 (control), 5, 50, and 500 mg/kg/day, from day 15 of pregnancy to day 21 after parturition. The animals were allowed to deliver and their offspring were examined for postnatal growth and development. No signs of toxic effects related to the test material were observed in the dams F0 during pregnancy and lactation. No adverse effects were observed on the postnatal growth, behaviours, or reproductive ability of pups F1. The physical and sensorial development of pups F2 was also normal. These results confirm that Policosanol does not affect the reproductive performance or fetal/neonatal development.

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