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Evaluation of p53 genotype on gene expression in the testis, liver, and heart from male C57BL/6 mice

✍ Scribed by Dayton M. Petibone; Rohan M. Kulkarni; Ching-Wei Chang; James J. Chen; Suzanne M. Morris

Book ID
113080536
Publisher
Springer Netherlands
Year
2011
Tongue
English
Weight
183 KB
Volume
21
Category
Article
ISSN
0962-8819

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## Abstract C3H/HeJ(C3H) mice are approximately 50‐fold more susceptible to liver‐tumor induction than C57BL/6J(B6) mice. This difference in susceptibility is a consequence of allelic differences in hepatocarcinogen sensitivity(__Hcs__) genes that control the growth of preneoplastic lesions in the