Evaluation of non-polar interactions in chiral recognition by alkylated β- and γ-cyclodextrin chiral stationary phases
✍ Scribed by Ivan Spanik; Peter Oswald; Jan Krupcik; Eva Benicka; Pat Sandra; Daniel W. Armstrong
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 130 KB
- Volume
- 25
- Category
- Article
- ISSN
- 1615-9306
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✦ Synopsis
Evaluation of non-polar interactions in chiral recognition by alkylated b-and c-cyclodextrin chiral stationary phases
The gas chromatographic separation of enantiomers of seven N-TFA-O-alkyl amino acid derivatives was studied on four different permethyl- andOpentyl-b-and -c-CD stationary phases.It was shown that the separation of enantiomers N-TFA-O-alkyl amino acid derivatives depends both on the length of the linear alkyl chain attached to the stereogenic carbon (R 1 ) and to the ester part of the amino acid derivative (R 2 ). The cyclodextrin cavity size also affected selectivity. The separation of the amino acid derivatives decreases with increasing length of both the R 1 and R 2 alkyl chains on b-CD stationary phases, but improves on c-CD stationary phases. The separation of enantiomers of all N-TFA-O-methyl amino acid esters, is better on the larger c-cyclodextrin CSPs except for enantiomers of N-TFA-O-alkyl esters of alanine which are better separated on b-CD stationary phases.