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Evaluation of native and exotic Brazilian plants for anticancer activity

✍ Scribed by Helvécio Martins dos Santos Júnior; Denilson Ferreira Oliveira; Douglas Antônio de Carvalho; Joyce Mendes Andrade Pinto; Viviane Aparecida Costa Campos; Ana Raquel Braga Mourão; Cláudia Pessoa; Manoel Odorico de Moraes; Letícia Veras Costa-Lotufo

Book ID
107343784
Publisher
Springer Japan
Year
2010
Tongue
Japanese
Weight
203 KB
Volume
64
Category
Article
ISSN
1340-3443

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Synthesis and biological evaluation of novel triptolide analogues for anticancer activity
✍ Bing Zhou; Zehong Miao; Gang Deng; Jian Ding; Yaxi Yang; Huijin Feng; Yuanchao L 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 672 KB

Three types of novel triptolide analogues with 9,11-olefin (3-5), five-membered unsaturated lactam ring (6-7) or A/B cis ring junction (8-14) were synthesized. Although with 9,11-olefin instead of 9,11-β-epoxide, compound 4a was much more active than the parent natural triptolide (1) with the lowest