Evaluation of N-Hydroxymethylphthalimide in Alkaline Medium: Novel Entry to the Tricyclic [1,3]Oxazepine Core via an Intramolecular π and O-Cationic Cyclization.

Evaluation of N-hydroxymethylphthalimide

Evaluation of N-hydroxymethylphthalimide in alkaline medium: Novel entry to the tricyclic [1,3]oxazepine core via an intramolecular π and O-cationic cyclization

✍ Armelle Cul; Anthony Pesquet; Adam Daïch; Abderrahim Chihab-Eddine; Štefan March 📂 Article 📅 2003 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 119 KB

## Abstract Fused isoindolo[1,3]benzo(or thieno)oxazepines **8a,b** and one of their positional isomers aromatic tricyclic __N,O__‐acetals **13b** are reported to occur efficiently in a three‐step sequence from __N__‐hydroxy‐methylphthalimide **(6)**. The key step of this methodology is the intramo