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Evaluation of methotrexate tissue exposure by in situ microdialysis in a rat model

✍ Scribed by Per O. Ekstrøm, Anders Andersen, David J. Warren…

Book ID
120777365
Publisher
Springer
Year
1994
Tongue
English
Weight
557 KB
Volume
34
Category
Article
ISSN
0344-5704

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✍ Dr. Pauline de la M. Hall; Mark A. Jenner; Michael J. Ahern 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 669 KB

We undertook a dose-response study in Wistar rats to develop an animal model for methotrexate hepatotoxicity. Rats were given oral methotrexate in 300, 200, 150 and 100 pg/kg/day doses for variable lengths of time. The 300 pg/kg/day dose produced systemic toxicity; the animals needed to be killed ea