Evaluation of methods for predicting the topology of β-barrel outer membrane proteins and a consensus prediction method
✍ Scribed by Pantelis G Bagos; Theodore D Liakopoulos; Stavros J Hamodrakas
- Book ID
- 115000099
- Publisher
- BioMed Central
- Year
- 2005
- Tongue
- English
- Weight
- 376 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1471-2105
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## Abstract Prediction of membrane spanning segments in β‐barrel outer membrane proteins (OMP) and their topology is an important problem in structural and functional genomics. In this work, we propose a method based on radial basis networks for predicting the number of β‐strands in OMPs and identi
A new dataset of 396 protein domains is developed and used to evaluate the performance of the protein secondary structure prediction algorithms DSC, PHD, NNSSP, and PREDATOR. The maximum theoretical Q 3 accuracy for combination of these methods is shown to be 78%. A simple consensus prediction on th