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Evaluation of mathematical models for diffusion from semisolids

✍ Scribed by James W. Ayres; Paul A. Laskar

Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
531 KB
Volume
63
Category
Article
ISSN
0022-3549

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✦ Synopsis

Models used in the description of diffusion processes were applied to drug release from semisolids. Two models, an exponential model for finite systems and a nonexponential model for semi-infinite and infinite systems, are evaluated for their suitability in describing literature data for release of substances from semisolids. The regression lines calculated for these data are evaluated using analysis of variance and examination of residuals. Evaluation of these models using these data indicates that the exponential model derived for finite systems is applicable in all the literature cases while the nonexponential model has restricted applicability.

Keyphrases 0 Diffusion, drugs from semisolids-exponential and monoexponential models evaluated using literature data, regression lines calculated 0 Semisolids-evaluation of mathematical models used to describe drug diffusion 0 Ointments-evaluation of mathematical models used to describe drug diffusion 0 Drug diffusion from semisolids-exponential and monoexponential models evaluated using literature data, regression lines calculated

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