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Evaluation of LY163443, 1-[2-hydroxy-3-propyl-4-{[4-(1H-tetrazol-5-ylmethyl)phenoxy]methyl}phenyl]ethanone, as a pharmacologic antagonist of leukotrienes D4and E4

โœ Scribed by Jerome H. Fleisch; Lynn E. Rinkema; Klaus D. Haisch; Doris McCullough; F. Patrick Carr; Robert D. Dillard


Book ID
112375881
Publisher
Springer-Verlag
Year
1986
Tongue
English
Weight
847 KB
Volume
333
Category
Article
ISSN
0028-1298

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## Abstract The effects of LYโ€171883, an orally active leukotriene antagonist, on membrane currents were examined in pituitary GH~3~ and in neuroblastoma IMRโ€32 cells. In GH~3~ cells, LYโ€171883 (1โ€“300 ฮผM) reversibly increased the amplitude of Ca^2+^โ€activated K^+^ current in a concentrationโ€depende