Insulin glargine (Lantus 1 , Aventis Pharma, Deutschland, GmbH) is a new long-acting human insulin analog. Structural modification of the insulin molecule at two sites alters its pH, causing insulin glargine to precipitate in the neutral environment of subcutaneous tissue and to form a depot that is
Evaluation of Lipopolysaccharide Aggregation by Light Scattering Spectroscopy
โ Scribed by Nuno C. Santos; Ana C. Silva; Miguel A. R. B. Castanho; J. Martins-Silva; Carlota Saldanha
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 106 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1439-4227
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Aggregation behavior and hydrodynamic parameters of insulin have been determined from static and dynamic light scattering experiments and intrinsic viscosity measurements carried out at pH 4.0, 7.5, and 9.0 in the temperature range 20-40ะC in aqueous solutions. The protein aggregated extensively at