✦ LIBER ✦

Evaluation of intrinsic immobilized kinetic parameters for factor X activation in a flow reactor

✍ Scribed by Srikant Gir

Publisher: Springer Netherlands
Year: 1995
Tongue: English
Weight: 231 KB
Volume: 17
Category: Article
ISSN: 0141-5492
DOI: 10.1007/bf00128397

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✦ Synopsis

Development of a double exponential model for determining the intrinsic kinetic parameters for factor X activation by tissue factor-factor VIIa (TF:VIIa) complex, during the complete course of the reaction in a flow reactor is described. The model data reveal that the factor X activation rate constant K i gradually increased from 0.0225 to 0.0456 min -i as the shear rate increased from 50 to 3000 sec -i, whereas the factor Xa inhibition rate constant K 2 increased dramatically from 0.307 to 1.09 min -i for a similar increase in shear rate.

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