Peptide mimetics as enzyme inhibitors: U
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Piotr Cieplak; Peter A. Kollman
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Article
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1993
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Springer Netherlands
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English
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We present the application of free energy perturbation theory/molecular dynamics to predict the consequence of replacing each of the seven peptide bonds in the potent HIV protease inhibitor JG365: ACE (acetyl)-Ser-Leu-Asn-HEA (hydroxyethylamine analog of Phe-Pro)-Ile-Val-NME (N-methyl) by ethylene o