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Evaluation of inhibition of fatty acid synthase by ursolic acid: Positive cooperation mechanism

✍ Scribed by Yang Liu; Weixi Tian; Xiaofeng Ma; Wenjun Ding


Book ID
116299768
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
470 KB
Volume
392
Category
Article
ISSN
0006-291X

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The antibiotic, thiolactomycin, is known to selectively inhibit the Type II straight-chain fatty acid synthase (monofunctional enzyme system, e.g. Escherichia coli enzyme) but not Type I straight-chain fatty acid synthase (multifunctional enzyme system, e.g. Saccharomyces cerevisiae enzyme). We have