Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure–activity relationship (QSAR) with the Abraham descriptors

✍ Scribed by Yuan H. Zhao; Joelle Le; Michael H. Abraham; Anne Hersey; Peter J. Eddershaw; Chris N. Luscombe; Darko Boutina; Gordon Beck; Brad Sherborne; Ian Cooper; James A. Platts

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 350 KB
• Volume: 90
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.1031

✦ Synopsis

The human intestinal absorption of 241 drugs was evaluated. Three main methods were used to determine the human intestinal absorption: bioavailability, percentage of urinary excretion of drug-related material following oral administration, and the ratio of cumulative urinary excretion of drug-related material following oral and intravenous administration. The general solvation equation developed by Abraham's group was used to model the human intestinal absorption data of 169 drugs we considered to have reliable data. The model contains ®ve Abraham descriptors calculated by the ABSOLV program. The results show that Abraham descriptors can successfully predict human intestinal absorption if the human absorption data is carefully classi®ed based on solubility and administration dose to humans.