Evaluation of hepatocellular function by way of receptor-mediated uptake of a technetium-99m—labeled asialoglycoprotein analog
✍ Scribed by Neville R. Pimstone; Robert C. Stadalnik; David R. Vera; Dusan P. Hutak; Walter L. Trudeau
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 613 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
✦ Synopsis
We have developed a quantitative functional imaging study of the liver using a radiolabeled asialoglycoprotein analog, Tc-galactosyl-neoglycoalbumin. Heart and liver time-activity data can be transformed by automated kinetic analysis into asialoglycoprotein hepatocyte receptor concentration. Twenty-eight healthy controls, 46 patients with noncholestatic chronic liver injury and 11 patients with primary biliary cirrhosis were studied. Liver function was also assessed by Pugh modified-Child-Turcotte criteria, 14C-aminopyrine breath test and indocyanine green clearance (24 patients).
Results:
(a) in normal controls with a child-turcotte criteria score of 5, receptor concentration ranged from 0.63 to 1.19 mumol/l, with a mean 0.83 +/- 2 s.d. 0.06 mumol/l, which was significantly higher (p < 0.001) than that of the patient group (mean receptor concentration = 0.44 +/- 2 s.d. 0.04 mumol/l). in cirrhotic patients with child-turcotte criteria score of 5, the mean receptor concentration was 0.60 +/- 2 s.d. 0.07 mumol/l, which was significantly lower than controls (p < 0.01). in end-stage cirrhosis (child-turcotte criteria score 11 to 15), a group in which patients died or required orthotopic liver transplantation within 1 yr, the mean receptor concentration was 0.35 +/- 2 s.d. to 0.07 mumol/l. the sensitivity and specificity for receptor concentration in relation to liver disease, with values above 0.65 mumol/l being normal, were 0.96 and 0.88, respectively. receptor concentration correlated well with child-turcotte criteria score (r = 0.78, p = < 0.001), with aminopyrine breath test (r = 0.75, p = < 0.001) and with indocyanine green clearance (r = 0.88, p = < 0.001).(abstract truncated at 250 words)