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Evaluation of Hepatic and Renal Function in Cats with Chediak-Higashi Syndrome

✍ Scribed by K. Jane Wardrop; Cheryl R. Dhein; David J. Prieur; Kenneth M. Meyers


Book ID
114950839
Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
469 KB
Volume
16
Category
Article
ISSN
0147-0701

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Chediak-Higashi syndrome (CHS) is an auto-soma1 recessive disease in humans, cats, and 8 other species. The homology of CHS in humans and cats has been demonstrated. Since human CHS is a progressive, serious, and eventually fatal disease, a method for prenatal diagnosis would be desirable. This stud

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## Abstract Cats with the Chediak‐Higashi (CH) syndrome have abnormal hemostasis with prolonged bleeding times and normal coagulation times. Platelet aggregation induced by serotonin, ADP, and collagen was impaired. Platelets from normal and CH cats were incubated with ^14^C‐adenine and then gel‐fi