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Evaluation of glycoprotein constituents in head and neck cancer patients undergoing radiotherapy

✍ Scribed by Rakesh M. Rawal; Prabhudas S. Patel; Beena P. Patel; Gira N. Raval; Mintoo M. Patel; Jyotsna M. Bhatavdekar; Sanjay A. Dixit; Devendra D. Patel

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 138 KB
Volume: 21
Category: Article
ISSN: 1043-3074
DOI: 10.1002/(sici)1097-0347(199905)21:3<192::aid-hed2>3.0.co;2-d

No coin nor oath required. For personal study only.

✦ Synopsis

Background. Alterations in serum levels of several glycoprotein constituents are reported to be useful for treatment monitoring of cancer patients. The purpose of this study was to determine efficacy of sialic acid and seromucoid fraction as treatment monitors for head and neck (H&N) cancer patients undergoing radiotherapy (RT).

Methods. Serum levels of total sialic acid (TSA), lipid-bound sialic acid (LSA), and seromucoid fraction (measured as Mucoid protein [MP] and hexose) were studied in age matched controls and in patients with H&N cancer at diagnosis and during/after completion of RT. The markers were estimated by spectrophotometric methods.

Results. Serum levels of sialic acid forms and seromucoid fraction were significantly elevated (p < .001) in untreated H&N cancer patients (n = 32) as compared with controls (n = 50). The marker levels were significantly declined (p < .001) in H&N can-cer patients who responded to RT as compared with their levels at diagnosis, whereas the levels were persistently elevated in nonresponders.

Conclusion. Evaluation of sialic acid forms and seromucoid fraction could be used for monitoring the treatment of H&N cancer patients undergoing RT.

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