Evaluation of free radical scavenging of dietary carotenoids by the stable radical 2,2-diphenyl-1-picrylhydrazyl

Oxidation of HMG-CoA reductase inhibitor

Oxidation of HMG-CoA reductase inhibitors by tert-butoxyl and 1,1-diphenyl-2-picrylhydrazyl radicals: Model reactions for predicting oxidatively sensitive compounds during preformulation

✍ Shyam B. Karki; Varaporn Treemaneekarn; Michael J. Kaufman 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 200 KB 👁 1 views

Hydrogen atom abstraction rate constants for the reaction of tert-butoxyl and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical with the HMG-CoA reductase inhibitors lovastatin, simvastatin, and statins I-IV were measured. This series of diene-containing drugs is known to be prone to oxidation. The tert-