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Evaluation of four methods for scoring cytoplasmic grains in the in vitro unscheduled DNA synthesis (UDS) assay

โœ Scribed by P.R. Harbach; H.J. Rostami; C.S. Aaron; S.K. Wiser; C.R. Grzegorczyk


Book ID
113252103
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
595 KB
Volume
252
Category
Article
ISSN
0165-1161

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We have evaluated the use of four different positive control compounds for assessing UDS in monkey hepatocytes and have found three of these, methylmethanesulfonate, benzo[a]pyrene, and dimethylbenz[a]anthracene, to produce strong positive responses in vitro. Dimethylnitrosamine induced only weak re