## Background: Decreased maternal folate levels are associated with having a child with a neural tube defect (ntd), and periconceptual folic acid supplementation reduces this risk by >50%. vitamin b(12) (as methylcobalamin) is a cofactor for methionine synthase, an enzyme that plays a key role in f
β¦ LIBER β¦
Evaluation of folate metabolism gene polymorphisms as risk factors for open and closed neural tube defects
β Scribed by K. Doudney; J. Grinham; J. Whittaker; S.A. Lynch; D. Thompson; G.E. Moore; A.J. Copp; N.D.E. Greene; P. Stanier
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 75 KB
- Volume
- 149A
- Category
- Article
- ISSN
- 1552-4825
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## Abstract Abnormal folate/homocysteine metabolism due to polymorphisms in genes involved in this pathway has been implicated as an etiologic factor in Down syndrome (DS). This caseβcontrol study aimed to evaluate the effect of maternal C677T and A1298C polymorphisms of the methylenetetrahydrofola