✦ LIBER ✦

Evaluation of energy metabolism in brain using epimerization of 2-deoxy-2-fluoro-d-glucose by 19F NMR: The effect of anesthesia

✍ Scribed by Shunji Shinohara; Yoko Kanazawa; Masaharu Kojima

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 375 KB
Volume: 21
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910210204

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The effect of anesthesia on the epimerization of 2‐deoxy‐2‐fluoro‐D‐glucose(‐6‐phosphate) to 2‐deoxy‐2‐fluoro‐D‐mannose(6‐phosphate) in mice was demonstrated with ^19^F NMR spectroscopy of excised tissue specimens from heart, muscle, and brain. Spectra from each of six excised organs confirmed that pretreatment with an anesthetic suppressed the conversion ratio, FDM/(FDG + FDM), in brain at 3 h from 52 ± 5 to 30 ± 6% under the dose of 100 mg/kg. We propose potential applications for NMR monitoring of FDG‐FDM conversion, including the assessment of regional brain metabolism and the evaluation of Various pharmacologic agents. © 1991 Academic Press, Inc.

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