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Evaluation of effects on cardiac contractility in conscious common marmosets using telemetry

โœ Scribed by Tetsuya Kitayama; Takashi Saito; Masatomo Kajihara; Katsuhiko Harada


Book ID
118503618
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
68 KB
Volume
66
Category
Article
ISSN
1056-8719

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Desethylamiodarone (DEA), the mjor active metabolite of amiodarone (AMD), plays a significant role in the electrophysiological effects observed during AMD thexapy. The pharmacokinetics and pharmacodynamics of DEA wcre studied in rats. Animals were administered DEA (20 or 40 mg kg-I) and blood sample