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Evaluation of different partial AUCs as indirect measures of rate of drug absorption in comparative pharmacokinetic studies

โœ Scribed by C. Duquesnoy; L.F. Lacey; O.N. Keene; A. Bye


Book ID
117628472
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
96 KB
Volume
6
Category
Article
ISSN
0928-0987

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Evaluation of different indirect measure
โœ L. F. Lacey; O. N. Keene; C. Duquesnoy; A. Bye ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 414 KB

As indirect measures of rate of drug absorption (metrics), maximum plasma concentration (C-) is confounded by extent of drug absorption and the time to reach C , , (t-) is a discrete variable, dependent on blood sampling frequency. Building on the work of Endrenyi et al., we have compared different