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Evaluation of demographic, clinical characteristics, and genetic polymorphism as risk factors for pelvic organ prolapse in brazilian women

✍ Scribed by Karina de Falco Martins; Zsuzsanna Ilona Katalin de Jármy-Di Bella; Andrea Moura Rodrigues Maciel da Fonseca; Rodrigo Aquino Castro; Ismael Dale Cotrim Guerreiro da Silva; Manoel João Batista Castello Girão; Marair Gracio Ferreira Sartori

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 215 KB
Volume: 30
Category: Article
ISSN: 0733-2467
DOI: 10.1002/nau.21066

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Objective

Verify the association between genital prolapse, other risk factors and a polymorphism in exon 31 of the collagen III‐a1 gene (COL3A1).

Setting

The etiology of genital prolapse is multifactorial, and genetic defects have been proposed. Also, there is evidence that changes in collagen may be responsible for defects in pelvic floor support. The exon 31 polymorphism results in structural changes in the triple helical of the collagen and appears to lead to abnormal synthesis of type III collagen.

Design

Basic science study.

Population

The studied group consisted of 107 patients with stage III and IV genital prolapse (POP‐Q). The control group included 209 women with stage 0 and I prolapse.

Methods

After extracting genomic DNA from the peripheral blood, the exon 31 COL3A1 polymorphism was typed by restriction fragment length polymorphism analysis.

Main outcome measures

Association between genital prolapse and exon 31 COL3A1 polymorphism.

Results

No statistically significant differences in genotype and allele frequencies were found between cases and controls (P = 0.75 and 0.66, respectively). Multiple logistic regression analyses identified age (OR = 1.05; 95%CI = 1.01–1.10), BMI (OR = 1.09; 95%CI = 1.01–1.17), presence of at least one vaginal delivery (OR = 7.22; 95%CI = 1.84–28.27), positive family history of POP (OR = 2.27; 95%CI = 1.05–4.93) and a macrosomic foetus (OR = 2.91; 95%CI = 1.24–6.79) as independent risk factors for genital prolapse. In contrast, the number of caesarean deliveries was found to be an independent protective factor (OR = 0.43; 95%CI = 0.24–0.78).