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Evaluation of Cissus quadrangularis extracts as an inhibitor of COX, 5-LOX, and proinflammatory mediators

โœ Scribed by Arti M. Bhujade; Suhas Talmale; Naresh Kumar; Geetika Gupta; P. Reddanna; Samar K. Das; M.B. Patil


Book ID
116645863
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
949 KB
Volume
141
Category
Article
ISSN
0378-8741

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Fourteen new 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives were synthesized. Six compounds displayed potent inhibitory activities against COX-1/2 and 5-LOX with IC 50 in the range of 0.10-9.87 lM. Particularly, 10f exhibited well balanced inhibitory action on these enzymes (I