Evaluation of chlorofusin, its seven chromophore diastereomers, and key analogues

✍ Scribed by Ryan C. Clark; Sang Yeul Lee; Inkyu Hwang; Mark Searcey; Dale L. Boger

• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 256 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2009.01.081

✦ Synopsis

Chlorofusin, its seven chromophore diastereomers, and key analogues were comparatively examined for inhibition of MDM2-p53 binding revealing that the chromophore, but not simple replacements, contributes significantly to the natural products properties, and that this contribution is independent of its relative and absolute stereochemistry.