Evaluation of skin damage caused by perc
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Yasuko Obata; Takahiro Sesumi; Kozo Takayama; Koichi Isowa; Sharon Grosh; Steve
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Article
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2000
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John Wiley and Sons
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English
⚖ 158 KB
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Fractal analysis of the cross-sectional morphology of rat skin was conducted to evaluate pathologic changes evoked by percutaneous absorption enhancers. Male hairless rats (WBN/Ht-ILA), 8 weeks old, weighing 160 to 180 g were used. Under anesthetization, glass cells (10-mm inner diameter) were attac