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Evaluation of carcinogenicity and chronic toxicity associated with orthopedic implants in mice

✍ Scribed by Takamura, Kazuyuki ;Hayashi, Kazuo ;Ishinishi, Noburu ;Yamada, Teruki ;Sugioka, Yoichi

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 649 KB
Volume: 28
Category: Article
ISSN: 0021-9304
DOI: 10.1002/jbm.820280508

No coin nor oath required. For personal study only.

✦ Synopsis

The carcinogenicity and chronic toxicity of 316L stainless of them. Tumors retaining nickel alloys were malignant steel, nickel, Ti-6A1-4V, hydroxyapatite (HA)-coated Ti-fibrous histiocytoma or fibrosarcoma. In some cases, 6A1-4V, aluminum oxide containing yttrium oxide, lymphomata that seemed to develop spontaneously and zirconium oxide containing yttrium oxide were were found around the implants because lymphocytes evaluated by implanting solid rods of each material were known to accumulate in chronic inflammatory in the thigh muscle of C57BL/6N mice for 24 months. lesions, and this phenomenon also might be applied to Nickel alloy showed high carcinogenic and toxic lymphoma.

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