✦ LIBER ✦

Evaluation of bone healing with eggshell-derived bone graft substitutes in rat calvaria: A pilot study

✍ Scribed by Jin-Woo Park; Sang-Ryul Bae; Jo-Young Suh; Dong-Hee Lee; Sang-Hyun Kim; Hyungjun Kim; Chong-Soo Lee

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 610 KB
Volume: 87A
Category: Article
ISSN: 1549-3296
DOI: 10.1002/jbm.a.31768

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The purpose of this study was to investigate the potential effectiveness of a surface‐modified natural calcium carbonate, hen eggshell (ES) as a bone graft substitute. The surface characteristics, cell viability on, and osteoconductivity of, particulated ES with and without hydrothermal treatment in phosphate solutions were evaluated. Hydrothermal treatment partially converted ES to calcium‐deficient hydroxyapatite (HA) with surface microstructure. MTT assay indicated higher osteoblast viability on surface‐modified ES compared with a commercially available bone substitute, anorganic bovine bone (Bio‐Oss, BO) (p < 0.001). Histological and histomorphometric analysis showed significantly greater new bone formation and mineralized bone‐to‐graft contact of surface‐modified ES, especially with hydrothermally treated ES, compared with BO in 5‐mm diameter calvarial defects in rats at 4 and 8 weeks of healing (p < 0.01). Complete bony bridging was more frequently found with hydrothermally treated ES. The results of this pilot study indicate the potential efficacy of surface‐modified particulated hen eggshell as an osteoconductive bone substitute in a rat calvarial defect model. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008

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