Evaluation of an oral sustained release dosage form of trimeprazine as measured by urinary excretion

✍ Scribed by K. R. Heimlich; D. R. MacDonnell; Andrew Polk; T. L. Flanagan

• Publisher: John Wiley and Sons
• Year: 1961
• Tongue: English
• Weight: 299 KB
• Volume: 50
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600500308

✦ Synopsis

Effectiveness of sustained release dosage forms of trimeprazine tartrate, as pellets with varying thicknesses of a slowly digestible wax-fat mixture, is measured by determining the urinary excretion of the drug or its metabolites during specified periods after ingestion. Results are compared with in vitro tests. NE OF THE GREATEST difficulties encountered 0 in the development of sustained release dosage forms is the procurement of human in vivo data which adequately demonstrate the sus-