Evaluation of alternative strategies to optimize ketorolac transdermal delivery
β Scribed by Carmelo Puglia; Rosanna Filosa; Antonella Peduto; Paolo de Caprariis; Luisa Rizza; Francesco Bonina; Paolo Blasi
- Book ID
- 111767302
- Publisher
- Springer US
- Year
- 2006
- Tongue
- English
- Weight
- 203 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1530-9932
- DOI
- 10.1208/pt070364
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π SIMILAR VOLUMES
Alkyl esters of ketorolac were synthesized as potential prodrugs for transdermal delivery and evaluated to determine the relationship between their skin permeation characteristics and their physicochemical properties. Solubility of the prodrugs in various vehicles was determined at room temperature
This investigation includes an evaluation of the percutaneous absorption of bupropion (BUP) and hydroxybupropion (BUPOH) in vitro and in vivo. In addition, a carbamate prodrug of BUPOH (But-BUPOH) was evaluated in vitro. In vitro diffusion studies were conducted in a flow-through diffusion cell syst