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Evaluation of a rapamycin-regulated serotype 2 adeno-associated viral vector in macaque parotid glands

✍ Scribed by C Zheng; A Voutetakis; M Metzger; S Afione; AP Cotrim; MA Eckhaus; VM Rivera; T Clackson; JA Chiorini; RE Donahue; CE Dunbar; BJ Baum

Book ID
111272456
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
330 KB
Volume
16
Category
Article
ISSN
1354-523X

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Long-term transduction of miniature pig
Long-term transduction of miniature pig parotid glands using serotype 2 adeno-associated viral vectors
✍ Bo Hai; Xing Yan; Antonis Voutetakis; Changyu Zheng; Ana P. Cotrim; Zhaochen Sha 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 322 KB

## Abstract ## Background Previously, using an adenoviral vector, we showed that miniature pigs could provide a valuable and affordable large animal model for pre‐clinical gene therapy studies to correct parotid gland radiation damage. However, adenoviral vectors lead to short‐term transgene expre