Tablets with a central hole and a water-impermeable coating were prepared. These perforated coated tablets (PCTs) dissolve and release drug through the central hole only. In vitro release of the model drugs sodium benzoate and benzamide from PCTs occurred at a constant rate up to 80% release. The ze
Evaluation of a perforated drug delivery system in mice for prolonged and constant release of a hydrophilic drug
โ Scribed by Ashish Rastogi; Phillip D. Bowman; Salomon Stavchansky
- Publisher
- Springer-Verlag
- Year
- 2012
- Tongue
- English
- Weight
- 226 KB
- Volume
- 2
- Category
- Article
- ISSN
- 2190-393X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The objective of this work was to develop and evaluate a floating-pulsatile drug delivery system intended for chronopharmacotherapy. Floating-pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase followed by a burst release. To overcome limitations of va
## Abstract In this study, drugโeluting cochlear implant (CI) electrodes were prepared, and the amount of drug released was determined. Dexamethasone (DEX) (0.25โ2% w/w, the weight percent of the final cured polymer) was used as a bioactive agent to suppress postsurgical inflammations upon mixing w
The aim of the present study was to investigate the effect of poly(acrylic acid)-cysteine (PAA-cysteine) exhibiting a molecular mass of 100 and 250 kDa and reduced glutathione (GSH) on the absorption of the P-glycoprotein (P-gp) and cytochrome P450 (CYP450) substrate paclitaxel in vitro and in vivo.