## Abstract ## Purpose To evaluate whether quantitative MRI parameters are sensitive to the effects of the tyrosine kinase inhibitor gefitinib and can discriminate between two different treatment protocols. ## Materials and Methods Untreated mice with BT474 breast tumor xenografts were character
Evaluation of a method to map tibiofemoral contact points in the normal knee using MRI
✍ Scribed by Jennifer M Scarvell; Paul N Smith; Kathryn M Refshauge; Howard R Galloway; Kevin R Woods
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 584 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0736-0266
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
A technique using magnetic resonance imaging (MRI) is proposed for analysis of knee motion that is practical in the clinical situation. T1 weighted fast spin echo (FSE) and spoiled gradient echo (GE) sequences were compared to image both knees at 15° intervals from 0° to 90° flexion, while unloaded and loaded. The medial and lateral tibiofemoral contact points were mapped reliably using both FSE sequences and GE sequences with intra‐class correlation~(2,1)~ of 0.96 (CI 99% = 0.94–0.97) and 0.94 (CI 99% = 0.91–0.97), respectively. Results were consistent with the current literature on knee motion: the medial and lateral tibiofemoral contact pathways were different (F~1.80~ = 253.9, p < 0.0001) reflecting the longitudinal rotation of the knee, the loaded and unloaded knees were not different in the healthy knee (F~1.80~ = 0.007, p = 0.935), and the left and right knee were consistent for each individual (F~1.80~ = 0.005, p = 0.943). Therefore, right to left differences may be attributed to pathology. MRI analysis of knee kinematics as described by this technique of tibiofemoral contact point mapping provides a robust and reliable method of recording the tibiofemoral contact pattern of the knee. © 2003 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved.
📜 SIMILAR VOLUMES