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Evaluation of a mean field potential for protein folding with different interaction centers

✍ Scribed by María Larriva; David de Sancho; Antonio Rey

Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
938 KB
Volume
371
Category
Article
ISSN
0378-4371

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✦ Synopsis

We use Monte Carlo simulations to analyze the behavior of a family of previously reported, statistically derived, mean field potentials for protein folding (the DFIRE potentials from the Zhou laboratory). The potentials may consider different interaction centers (alpha carbons, beta carbons, or side-chain centroids), depending on the details of the coarsegrained model simulated. The type of association of the helices in different simulated coiled-coil proteins provides interesting information on the real capabilities of these interaction schemes along the sampling of the topological space available to the protein model.

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