✦ LIBER ✦
Evaluation of 31P NMR spectroscopy as an indicator of chemically induced hepatic toxicity in the rat: Comparison with serum enzyme levels and pathology
✍ Scribed by G. S. Sandhu; N. C. Gonnella; J. C. Kapeghian; A. F. Plocinski; J. Plutchok; M. J. Schlosser
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 362 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0952-3480
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✦ Synopsis
Tbe pmgresion of carbon tetrachloride-induced liver damage, determined by "P NMR spectroscopy, was compared with selected serum enzyme and btollogiepI changes in rats. ATP levels declined as early 88 8 h pOst-CQ addahtm tion, with partial recovery observed at l a b . Tbe results show that ATP r e d d o n correlates with necrosis. In addition, early d e d k in ATP occudng prior to signisant hepatocellular necrosis indicates abnormal energy metabolism.