Evaluation of 211At-labelled monodisperse polymer particles in vivo: Comparison of different specific activities
✍ Scribed by Roy H. Larsen; Tone Varaas; Per Hoff; Ignace B. Vergote; Jorolf Alstad; Laure N. De Vos; Kjell Nustad
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- French
- Weight
- 388 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
The a-particle emitter '''At was covalently coupled to 1.8 pm aminated monodisperse polymer particles (MDPP) and used to irradiate the intraperitoneal cavity in mice with disseminated turnour cells. Specific activity has previously been shown to influence the therapeutic efficacy of a-particle emitting compounds and the therapeutic efficacy of 2"At-h4DPP with various specific activity was therefore investigated. Groups of mice (10 animals per group) were treated with intraperitoneal injections of 100 kBq of *"At-MDPP with specific activities of 0.19, 0.55, 1.7, 5.0, 15, and 45 MBq/mg. A significantly prolonged survival was observed in the treated groups compared to the control group @om 19 to 26 days vs. 12 days, median). The difference in survival between the 211At-MDPP treated groups was not significant, but some animals with short survival were observed in