## Abstract Genomeβwide association (GWA) studies have recently emerged as a major approach to gene discovery for many complex diseases. Since GWA scans are expensive, cost efficiency is an important factor to consider in study design. However, it often requires extensive and timeβconsuming compute
β¦ LIBER β¦
Evaluating variations of genotype calling: a potential source of spurious associations in genome-wide association studies
β Scribed by Huixiao Hong; Zhenqiang Su; Weigong Ge; Leming Shi; Roger Perkins; Hong Fang; Donna Mendrick; Weida Tong
- Publisher
- Indian Academy of Sciences
- Year
- 2010
- Tongue
- English
- Weight
- 745 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0022-1333
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Genome-wide association studies (GWAS) have been frequently conducted on general or isolated populations with related individuals. However, there is a lack of consensus on which strategy is most appropriate for analyzing dichotomous phenotypes in general pedigrees. Using simulation studies, we compa