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Evaluating the mucoadhesive properties of drug delivery systems based on hydrated thiolated alginate

✍ Scribed by Maya Davidovich-Pinhas; Offer Harari; Havazelet Bianco-Peled


Book ID
113692708
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
706 KB
Volume
136
Category
Article
ISSN
0168-3659

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The aim of this study was the preparation and in vivo evaluation of a nasal insulin delivery system based on thiolated chitosan. 2-Iminothiolane was covalently attached to chitosan. The resulting conjugate (chitosan-TBA) exhibited 304.9 +/- 63.5 micromol thiol groups per gram polymer. Microparticles