Evaluating antimicrobials and implant materials for infection prevention around transcutaneous osseointegrated implants in a rabbit model
✍ Scribed by Teri G. Rosenbaum Chou; Cathy A. Petti; Juliana Szakacs; Roy D. Bloebaum
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 193 KB
- Volume
- 9999A
- Category
- Article
- ISSN
- 1549-3296
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✦ Synopsis
Abstract
Transcutaneous osseointegrated implants can improve function for select amputee patients, but infection serves as a significant limitation of implantable transcutaneous devices. This study examined the efficacy of an antimicrobial, pexiganan acetate (SUPONEX™), and a porous tantalum implant material (Trabecular Metal™) in preventing pin tract infection of osseointegrated implants in a rabbit model. Thirty‐seven rabbits were randomized to three groups: Ti‐control group (n = 11) with titanium alloy implant and no antimicrobial, Ti‐Pexiganan group (n = 8) with titanium alloy implant and topical pexiganan acetate 1% applied daily at the skin/implant interface, and Ta‐control group (n = 18) with porous tantalum implant and no antimicrobial. All implants were placed transcutaneously through skin, muscle, and bone. Rabbits were monitored for infection for 24 weeks. We observed a 75% reduction in rates of pin tract infection in the Ti‐Pexiganan group compared to that observed in the Ti‐control group (p = 0.019). No difference in rates of infection was observed between the Ta‐control group and the Ti‐control group (p = 0.230). In conclusion, pexiganan acetate may be an important antimicrobial for transcutaneous osseointegrated implants. Porous tantalum will not likely prevent pin tract infection without additional methods of soft tissue immobilization around the implant site. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010