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Eugenol reduces acute pain in mice by modulating the glutamatergic and tumor necrosis factor alpha (TNF-α) pathways

✍ Scribed by Wladmir Dal Bó; Ana Paula Luiz; Daniel F. Martins; Leidiane Mazzardo-Martins; Adair R.S. Santos


Book ID
115274325
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
206 KB
Volume
27
Category
Article
ISSN
0767-3981

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In response to the bacterial endotoxin, LPS, Kupffer cells are induced to express NO and TNF-␣. These compounds are involved in hepatic inflammation/injury, especially that associated with endotoxic shock. In this study, we demonstrate that ebselen (2-phenyl-1,2-benzisoselenazol-3[2H]one), a selenoo