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ETV6 fusion genes in hematological malignancies: A review

✍ Scribed by Etienne De Braekeleer; Nathalie Douet-Guilbert; Frédéric Morel; Marie-Josée Le Bris; Audrey Basinko; Marc De Braekeleer

Book ID
113773731
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
755 KB
Volume
36
Category
Article
ISSN
0145-2126

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The ETV6 (TEL) locus at chromosome band 12p13 is a major site of translocations in acute leukemia, particularly in childhood acute lymphoblastic leukemia (ALL). In cases with translocations involving ETV6, the normal ETV6 allele is often deleted. In addition, loss of heterozygosity of ETV6 is freque