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Etiology of neutrophilic granulocytic hypoplasia in a case of large granular lymphocytic leukemia with paraproteinemia

✍ Scribed by Friedman, Henry D. ;Goldberg, Jack ;Kurec, Anthony S. ;Davey, Frederick R.

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
429 KB
Volume
23
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

The association between large granular lymphocytic leukemia (LGLL) and neutropenia is poorly understood. We attempted to assess whether neutropenia in LGLL with paraproteinemia has a different etiology than LGLL without paraproteinemia. We found neither direct serum inhibition of granulocyte/monocyte‐colony forming units in vitro nor increased immunoglobulin binding to granulocytic neutrophils, neutrophil precursors, or granulocyte/monocyte‐colony stimulating factor. Clonogenic assay experiments suggested that suppression of the patient's granulocyte/monocyte‐colony forming units by the neoplastic T‐cells and decreased granulocyte/monocyte‐colony stimulating factor production contributed to the pathogenesis of neutropenia in this particular case. © 1994 Wiley‐Liss, Inc.

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