Etiological heterogeneity in Hodgkin's disease: HLA linked and unlinked determinants of susceptibility independent of histological concordance
✍ Scribed by Dr. Aravinda Chakravarti; Susan L. Halloran; Sherri J. Bale; Margaret A. Tucker; D. C. Rao
- Book ID
- 102843676
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 548 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0741-0395
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✦ Synopsis
Forty-one multiplex families, from published sources and new data from the National Cancer Institute, segregating for Hodgkin's disease and HLA, have been studied. A reanalysis of these data strongly suggests a recessive mode of inheritance for susceptibility to Hodgkin's disease. The HLA haplotype sharing data between affected relatives demonstrate that approximately 60 % of cases in multiplex families are due to an HLA-linked susceptibility gene, the remaining 40% being due to other familial factors. The data clearly support the hypothesis of etiological heterogeneity for Hodgkin's disease, with both HLA-linked and HLAunlinked factors being responsible. Finally, there is an increased concordance of histological types between affected relatives, but this concordance seems independent of HLA sharing.