𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Etiological aspects of congenital diaphragmatic hernia: results of a case comparison study

✍ Scribed by Albert P. Bos; Annemieke M. Pattenier; Rick E. Grobbee; Dick Lindhout; Dick Tibboel; Jan C. Molenaar

Book ID
104661209
Publisher
Springer
Year
1994
Tongue
English
Weight
199 KB
Volume
94
Category
Article
ISSN
0340-6717

No coin nor oath required. For personal study only.

✦ Synopsis

We report the results of a parental questionnaire concerning possible etiological and teratological factors, such as exposure to herbicides, in the development of congenital diaphragmatic hernia (CDH). The herbicide Nitrofen interferes with lung development in rats, can induce diaphragmatic hernia and greatly resembles thyroid hormone. No association with the studied teratogens nor with maternal thyroid dysfunction was found. The questionnaire was completed by 33 parents whose baby had CDH, and by 43 couples whose baby had oesophageal atresia. The resemblance of Nitrofen to thyroid hormone, a well-known growth factor for the developing lung, is of particular interest from a pathogenetic point of view in the development of CDH.

πŸ“œ SIMILAR VOLUMES

Environmental factors in the etiology of
Environmental factors in the etiology of esophageal atresia and congenital diaphragmatic hernia: Results of a case-control study
✍ Janine F. Felix; Marieke F. van Dooren; Merel Klaassens; Wim C. J. Hop; Claudine πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 102 KB πŸ‘ 3 views

## Abstract ## BACKGROUND: Esophageal atresia with or without tracheoesophageal fistula (EA/TEF) and congenital diaphragmatic hernia (CDH) are severe congenital anomalies. Their etiologies are mostly unknown and are thought to be multifactorial. No specific environmental factors have consistently